Dr. Psycho is a tiny little angry supervillain, gifted with the powers of psychosis and super-kinetic energies against his foe, Wonder Woman. His portrayal in various media ranges from being mentally deranged to having a deep seated hatred towards women.
The character of Doctor Psycho was created by William Moulton Marston, creator of Wonder Woman and author of her original adventures, as an allegory of the folly of abnormal emotions such as misogyny and other hatred, as well as to be another embodiment of what he called "less actively developed men"
Rob Matney, for the game he appears in, does a pretty good portrayal of the mad doctor. Actually, this is probably one of the better performances in the game for me, as it gives Psycho a good edge with his delivery.
Tony Hale does Psycho in the new Harley Quinn show, and he's one of the funniest performances in the show. His comedic delivery is on point, but as a result of the show's more comedy-slanted tone, Hale doesn't really show off the character's more sinister side.
I have no idea who to vote for as my favorite, but I'll probably go with Hale.