Medusa is the queen of the Inhumans, who are allies of the Fantastic Four and she first appeared in Fantastic Four #36 (March 1965). Her real name is Medusalith Amaquelin and she was born to Inhuman nutritionalists. She was exposed to the Terrigen Mists at a very young age and it gave Medusalith the ability to control her long hair in any form, such as appendages. As an adolescent, she would visit her distant cousin Black Bolt as he tried to control his powerful voice. With their frequent meetings, they fell in love and she learned to communicate with him, and together they made their own sign language until Black Bolt's eventual release. Around that time, Black Bolt's brother Maximus the Mad tried to take the throne from Black Bolt and during the conflict, Medusa was knocked of a sky-sled, losing her memory. She was found by Wizard and appeared as a member of his Frightful Four alongside the Sandman and Trapster and together they have clashed with the Fantastic Four many times. Eventually, her amnesia wore off and she returned to the Inhumans and married Black Bolt, serving as his translator.