Tsunade is the Fifth Hokage of the Hidden Leaf Village. Her grandfather was the First Hokage and granduncle was the Second Hokage. She is a former student of the Third Hokage and is one of the legendary Sannin along with Jiraiya and Orochimaru.
Tsunade is an expert in medical ninjustsu and has been named by many to be the world's strongest and most beautiful kunoichi.
Although she is actually very old (often called Grandma by Naruto) she maintains a young appearance from constant Transformation Techniques.
In the English dub version of the Naruto and Naruto: Shippuden anime series as well as the anime films, Tsunade is voiced by Debi Mai West. For several video games Tsunade is voiced by Mary Elizabeth McGlynn.